Reductive Debromination of 1-Methyl-2,4,5-tribromoimidazole Mediated by Dry Tetramethylammonium Fluoride in Aprotic Solvents
نویسندگان
چکیده
Neste trabalho investigou-se a reação entre fluoreto de tetrametilamônio seco (TMAF) e 1metil-2,4,5-tribromoimidazol em diferentes solventes apróticos polares. Nas reações feitas em DMSO, N,N-dimetilacetamida e N-metilpirrolidona, os principais produtos foram provenientes da desbrominação redutiva e não da fluoração, como esperado, mostrando que o TMAF é fortemente básico nestas condições. A reação feita em DMSO deuterado mostrou que o solvente é a principal fonte de próton. A dimetilformamida foi o solvente menos efetivo como doador de prótons, mas forneceu um rendimento significativo do produto fluorado 4,5-dibromo-2-flúor-1-metilimidazol.
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